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NIR-II AIEgens: A Win-Win Integration towards Bioapplications.

Wenhan Xu1, Dong Wang2, Ben Zhong Tang1

  • 1Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Neuroscience, Department of Chemical and Biological Engineering, and Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong, China.

Angewandte Chemie (International Ed. in English)
|June 10, 2020
PubMed
Summary

Aggregation-induced emission luminogens (AIEgens) enable advanced fluorescence imaging in the second near-infrared (NIR-II) window. These NIR-II AIEgens offer enhanced precision and theranostic capabilities for preclinical applications.

Keywords:
aggregation-induced emission (AIE)fluorescence imagingphotoacoustic imagingphotothermal therapy

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Area of Science:

  • Biomedical Optics
  • Materials Science
  • Nanotechnology

Background:

  • Fluorescence imaging in the second near-infrared (NIR-II) window is a rapidly developing field.
  • Aggregation-induced emission luminogens (AIEgens) are crucial for overcoming the limitations of traditional imaging techniques.
  • NIR-II AIEgens offer improved penetration depth and fluorescence efficiency for high-performance bioimaging.

Purpose of the Study:

  • To review recent advancements in molecular design strategies for NIR-II AIEgens.
  • To explore the diverse bioapplications of NIR-II AIEgens.
  • To identify current challenges and future prospects in the field of NIR-II AIEgens.

Main Methods:

  • Summarizing recent research on NIR-II AIEgens.
  • Analyzing molecular design principles for AIEgens.
  • Compiling examples of AIEgen applications in bioimaging and therapy.

Main Results:

  • NIR-II AIEgens demonstrate significant improvements in imaging precision and depth.
  • Some AIEgens enable bimodal imaging (fluorescence and photoacoustic).
  • AIEgens facilitate fluorescence imaging-guided photothermal therapy, creating theranostic platforms.

Conclusions:

  • NIR-II AIEgens represent a powerful tool for advanced biomedical imaging and theranostics.
  • Further development of molecular design strategies will unlock diverse applications.
  • Addressing current challenges will accelerate the preclinical translation of NIR-II AIEgen technology.