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H2S as a potential defense against COVID-19?
1Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada.
American Journal of Physiology. Cell Physiology
|June 10, 2020
Summary
Hydrogen sulfide (H2S) may offer a novel defense against COVID-19 pneumonia. This gasotransmitter shows potential in blocking viral entry, inhibiting replication, and reducing lung damage, suggesting its use as a preventative therapy.
Area of Science:
- Biochemistry
- Virology
- Pharmacology
Background:
- COVID-19, caused by SARS-CoV-2, is a global health emergency with no current vaccine or effective treatment.
- SARS-CoV-2 entry into host cells relies on ACE2 and TMPRSS2 proteins.
- Hydrogen sulfide (H2S) exhibits protective effects including anti-inflammation, antioxidation, and antiviral properties.
Purpose of the Study:
- To propose hydrogen sulfide (H2S) as a potential therapeutic agent against COVID-19.
- To review the known biological effects of H2S in the context of viral infections and lung damage.
Main Methods:
- Literature review of H2S signaling in biology and medicine.
- Analysis of H2S mechanisms relevant to SARS-CoV-2 infection and pathogenesis.
Main Results:
- H2S may inhibit SARS-CoV-2 entry by interfering with ACE2 and TMPRSS2.
- H2S could suppress viral replication by affecting virus assembly and release.
- H2S may mitigate lung damage by reducing inflammation and immune response.
Conclusions:
- Hydrogen sulfide presents a promising therapeutic strategy for COVID-19.
- Further preclinical and clinical investigations of H2S donors or enzyme activators are warranted for COVID-19 prevention and treatment.
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