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Paget's Disease of Bone and Cardiovascular Risk: A Pilot Study
Agostino Gaudio1, Luca Zanoli1, Anastasia Xourafa1
1Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Insights
Paget
Area of Science:
- Cardiovascular disease
- Bone metabolism
- Biomarkers
Background:
- Conflicting evidence suggests a link between Paget's disease of bone (PDB) and cardiovascular (CV) risk.
- PDB is a chronic disorder of bone remodeling.
Purpose of the Study:
- To investigate cardiovascular risk in Paget's disease of bone (PDB).
- To evaluate common carotid artery intima-media thickness (cIMT) and aortic pulse wave velocity (PWV) as CV risk markers in PDB patients.
Main Methods:
- A case-control study involving 12 patients with PDB and 58 age-matched controls.
- PDB diagnosis confirmed via clinical, radiological, and biochemical assessments.
- Measurements included cIMT and PWV.
Main Results:
- Patients with PDB exhibited significantly higher aortic pulse wave velocity (PWV) compared to controls.
- Common carotid artery intima-media thickness (cIMT) showed a non-significant increase in PDB patients.
- Results indicate increased arterial stiffness in PDB.
Conclusions:
- Paget's disease of bone is associated with increased arterial stiffness, as indicated by higher PWV.
- Potential contributing factors include elevated bone turnover and oxidative stress in PDB.
- Further research is warranted due to the small sample size.
Background:
The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting.
Objective:
Our study aimed to evaluate two markers of CV risk, namely, common carotid artery intimamedia thickness (cIMT) and the aortic pulse wave velocity (PWV) in patients with PDB.
Methods:
We enrolled 12 patients with PDB and 58 control subjects, matched for age. The diagnosis of PDB was based on clinical, radiological and biochemical parameters.
Results:
Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly but not significantly increased.
Conclusion:
These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or the high levels of oxidative stress that characterize this population.
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