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Acanthosis nigricans: A review.

Anupam Das1, Debatri Datta2, Martin Kassir3

  • 1Department of Dermatology, KPC Medical College and Hospital, Kolkata, India.

Journal of Cosmetic Dermatology
|June 10, 2020
PubMed
Summary

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Acanthosis nigricans (AN) is a treatable skin condition characterized by velvety, hyperpigmented plaques. While difficult to cure completely, weight reduction is the most effective management strategy for AN.

Area of Science:

  • Dermatology
  • Endocrinology

Background:

  • Acanthosis nigricans (AN) presents as symmetric, velvety, hyperpigmented plaques in intertriginous areas.
  • It is associated with various underlying conditions, including obesity and malignancy.

Purpose of the Study:

  • To review the pathophysiology and classification of AN.
  • To update diagnostic strategies and therapeutic options for AN based on current literature.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, EMBASE, MEDLINE, Cochrane).
  • Keywords included "acanthosis nigricans," "classification," "pathophysiology," "diagnosis," and "treatment."

Main Results:

  • AN pathophysiology involves multifactorial stimulation of keratinocyte and fibroblast proliferation.
Keywords:
acanthosis nigricansclassificationdiagnosispathophysiologytreatment

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  • Classifications include benign, obesity-associated, syndromic, malignant, and medication-induced types.
  • Management options encompass general measures (weight reduction), topical/oral drugs, chemical peels, and laser therapies.

    • Conclusions:

    • Acanthosis nigricans is treatable, though complete resolution is challenging.
    • Weight reduction is the primary management strategy.
    • Further research into AN pathophysiology and treatment is warranted.