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Ocular autonomic function in progressive autonomic failure.

C V Clark1, D J Ewing

  • 1University Department of Ophthalmology, Royal Infirmary, Edinburgh, UK.

Documenta Ophthalmologica. Advances in Ophthalmology
|December 1, 1988
PubMed
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Ocular autonomic function testing revealed abnormalities in patients with progressive autonomic failure (PAF). These findings suggest pupil cycle time and iris hypersensitivity can indicate generalized autonomic dysfunction.

Area of Science:

  • Ophthalmology
  • Autonomic Neuroscience
  • Neurology

Background:

  • Progressive autonomic failure (PAF) is a debilitating condition affecting the autonomic nervous system.
  • Early detection of autonomic dysfunction is crucial for timely intervention and management.
  • Ocular autonomic function has been explored as a potential indicator of systemic autonomic health.

Purpose of the Study:

  • To assess ocular autonomic function in patients diagnosed with progressive autonomic failure (PAF).
  • To evaluate the utility of pupil cycle time and iris denervation hypersensitivity as biomarkers for autonomic dysfunction.

Main Methods:

  • Measured pupil cycle time in 4 patients with PAF and age-matched controls.
  • Determined iris denervation hypersensitivity using methacholine (parasympathetic) and phenylephrine (sympathetic) challenges.

Related Experiment Videos

  • Compared ocular autonomic parameters between PAF patients and healthy control subjects.

    • Main Results:

    • Abnormal pupil cycle time was observed in all PAF patients; sustained cycling was absent in 5/8 tested eyes.
    • Significantly increased parasympathetic denervation hypersensitivity (methacholine response) in PAF patients (p < 0.001).
    • Significantly increased sympathetic denervation hypersensitivity (phenylephrine response) in PAF patients (p < 0.001).

    Conclusions:

    • Ocular autonomic function tests, including pupil cycle time and iris hypersensitivity, are significantly altered in PAF.
    • These ocular measures may serve as sensitive early indicators of generalized autonomic dysfunction.
    • Further research into ocular autonomic testing could enhance the diagnosis and monitoring of autonomic disorders.