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Updated: Dec 18, 2025

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A
Ikenna E Ndukwe1, Xiao Wang2, Nelson Y S Lam3
1Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Abstract:
Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent synthetic and biosynthetic reports, a rigorous study of the configuration of phormidolide A was necessary. This report outlines a synergistic effort employing computational and anisotropic NMR investigation, that provided orthogonal confirmation of the reassigned side chain, as well as supporting a further correction of the C7 stereocenter.
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