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Updated: Dec 18, 2025
Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
Published on: September 29, 2016
Inducing mesenchymal stem cell attachment on non-cell adhesive hydrogels through click chemistry
Alessia Battigelli1, Bethany Almeida1, Shashank Shukla1
1School of Engineering, Center for Biomedical Engineering, Institute for Molecular and Nanoscale Innovation, Brown University, Providence, Rhode Island 02912, USA. anita_shukla@brown.edu.
Abstract:
We introduce an innovative approach to adhere mesenchymal stem cells (MSCs) to a hydrogel scaffold by nucleating adhesion through strain-promoted click chemistry. This method yields a significant increase in cell viability compared to non-functionalized and RGD peptide functionalized hydrogels, providing a promising alternative to traditional biomaterials cell attachment approaches.
