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Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats
Fadwa El-Ouady1, Mohamed Eddouks1
1Departments of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine 52000, Errachidia, Morocco.
Aim:
The study was conducted to assess the antidiabetic and antihyperlipidemic effects of Lippia citriodora.
Background:
Lippia citriodora Kunth (Verbenaceae) is a medicinal plant with many traditional uses.
Objective:
The goal of this study was to investigate the antidiabetic activity of aqueous extract of Lippia citriodora and its capacity to improve the lipid profile in diabetic rats.
Methods:
Normal and diabetic rats were treated orally for 15 days by the leaves aqueous extract of Lippia citriodora (LCLAE) (100 mg/kg). The whole glucose utilization and liver architecture were also evaluated. The in vitro antioxidant activity of LCLAE was also assessed.
Results:
LCLAE lowered blood glucose and lipid levels in all groups. Moreover, LCLAE ameliorated the liver structure and exhibited antioxidant activity.
Conclusion:
In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of LCLAE in rats.
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