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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in

Jee Hee Yoo1,2, Sung Woon Park1, Ji Eun Jun3

  • 1Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Diabetes/Metabolism Research and Reviews
|June 11, 2020
PubMed

Insights

Low skeletal muscle mass and sarcopenic obesity are linked to diastolic dysfunction in adults. This highlights the importance of body composition in heart health, particularly in older populations.

Area of Science:

  • Cardiology
  • Geriatrics
  • Nutritional Science

Background:

  • Heart failure with preserved ejection fraction (HFpEF) is a growing global health concern, exacerbated by an aging population.
  • The relationship between low skeletal muscle mass, sarcopenic obesity, and left ventricular diastolic dysfunction is not well understood.
  • Investigating these associations is crucial for understanding HFpEF development.

Purpose of the Study:

  • To examine the association between low skeletal muscle mass, sarcopenic obesity, and diastolic dysfunction.
  • To analyze these relationships in a large cohort of Korean adults.
  • To provide insights into the pathophysiology of diastolic dysfunction in aging populations.

Main Methods:

  • A cross-sectional study involving 31,258 adults who underwent health examinations.
  • Skeletal muscle mass was quantified using the skeletal muscle mass index (SMI) via bioelectrical impedance analysis.
  • Echocardiography was employed to assess cardiac structure and function, specifically left ventricular diastolic function.

Main Results:

  • Diastolic dysfunction was identified in 9.78% of the study cohort.
  • Lower SMI tertiles were significantly associated with increased odds of diastolic dysfunction (OR: 1.56).
  • Sarcopenic obesity showed the highest risk for diastolic dysfunction (OR: 1.70), followed by obesity-only and sarcopenia-only.

Conclusions:

  • Reduced skeletal muscle mass and sarcopenic obesity are significantly associated with diastolic dysfunction.
  • These findings are consistent in both middle-aged and elderly populations (age ≥ 65 years).
  • Body composition, including muscle mass and obesity, plays a critical role in diastolic dysfunction.
Abstract

Keywords:
ageingdiastoleheart failureobesitysarcopeniaskeletal muscle

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