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Flavonoids in Cancer Metastasis
Alena Liskova1, Lenka Koklesova1, Marek Samec1
1Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
Cancers
|June 12, 2020
Summary
Flavonoids, natural compounds, show significant anti-cancer properties by inhibiting cancer cell migration and invasion. They offer a safe, cost-effective approach to complement cancer therapy and prevent metastasis.
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
Background:
- Metastasis is a major challenge in cancer treatment.
- Flavonoids are plant metabolites with diverse health benefits, including anti-cancer effects.
- Their role extends from early cancer stages to metastatic progression.
Purpose of the Study:
- To investigate the anti-metastatic effects of flavonoids.
- To explore their mechanisms of action against cancer cell migration and invasion.
- To assess their potential in cancer therapy and prevention.
Main Methods:
- In vitro and in vivo cancer models.
- Analysis of key signaling pathways regulating epithelial-mesenchymal transition (EMT).
- Evaluation of regulatory molecules like MMPs, uPA/uPAR, and TGF-β.
Main Results:
- Flavonoids inhibit cancer cell migration and invasion by regulating key signaling pathways.
- They modulate gene expression related to cancer progression and inflammation.
- Flavonoids enhance the efficacy of conventional chemotherapy with minimal side effects.
Conclusions:
- Flavonoids exhibit potent anti-metastatic effects across all cancer carcinogenesis phases.
- Their safety, cost-effectiveness, and bioavailability enhancement present promising therapeutic potential.
- Clinical research should explore flavonoids for targeted cancer prevention and therapy, especially in high-risk or metastatic cases.
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