Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

13.9K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
13.9K
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

208
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
208
Synthetic Biology02:55

Synthetic Biology

5.4K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.4K
Introduction to Biological Bases of Psychology01:30

Introduction to Biological Bases of Psychology

4.2K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
4.2K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

878
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
878

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ensuring continued access to essential inhaled respiratory medications: a call to action from the Inhaled Respiratory medicine Innovation and environmental Sustainability (IRIS) group.

The European respiratory journal·2026
Same author

Mechanistic insights into PFAS-induced effects on B lymphocyte activation and antibody secretion.

Archives of toxicology·2026
Same author

Using effect biomarker thresholds in regulatory risk assessment: an OECD-based framework for assessing cumulative exposures to chemical mixtures.

Environment international·2026
Same author

Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA).

ALTEX·2026
Same author

A quantitative definition for poorly soluble particles.

Particle and fibre toxicology·2026
Same author

Redefining the gold standard and recommendations to accelerate the adoption of New Approach Methodologies (NAMs) in support of the Three Rs.

Alternatives to laboratory animals : ATLA·2026
Same journal

Evaluation and interpretation of chemical genotoxicity risks; Strategies for method development.

Mutation research. Genetic toxicology and environmental mutagenesis·2026
Same journal

Oxide-nanoparticles induce in vitro DNA damage and genomic instability in human peripheral blood cells.

Mutation research. Genetic toxicology and environmental mutagenesis·2026
Same journal

LA-COMET group: In vivo application of the comet assay in animal and plant models, including wild species.

Mutation research. Genetic toxicology and environmental mutagenesis·2026
Same journal

Evaluation of applicability of the repeated-dose liver micronucleus assay in rats initiated at８weeks of age as in vivo genotoxicity assessment for 2,6-dninitrotoluene (2,6-DNT), a compound with reported cytostatic potential.

Mutation research. Genetic toxicology and environmental mutagenesis·2026
Same journal

Biomarkers and bioindicators of genotoxicity assessment of solid waste emissions from India: Insights into mechanisms of its genome instability.

Mutation research. Genetic toxicology and environmental mutagenesis·2026
Same journal

Alkaline comet assay in human biomonitoring studies by the Latin America / LA-COMET group.

Mutation research. Genetic toxicology and environmental mutagenesis·2026
See all related articles

Related Experiment Video

Updated: Dec 18, 2025

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

9.1K

Key read across framework components and biology based improvements.

Nicholas Ball1, Judith Madden2, Alicia Paini3

  • 1Dow Chemical Company, Horgen, Switzerland.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis
|June 12, 2020
PubMed
Summary
This summary is machine-generated.

Read across in toxicology uses chemical similarity to predict substance properties. Advanced algorithms and new methods, including in silico tools, enhance the accuracy and application of read across for toxicity assessment.

Keywords:
In silicoMetabolomicsPBPK modellingREACHRead-across

More Related Videos

Decoding Natural Behavior from Neuroethological Embedding
08:00

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

457
Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

686

Related Experiment Videos

Last Updated: Dec 18, 2025

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

9.1K
Decoding Natural Behavior from Neuroethological Embedding
08:00

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

457
Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

686

Area of Science:

  • Toxicology
  • Genomics
  • Computational Chemistry

Background:

  • The European Environmental Mutagen and Genomics Society (EEMGS) held a workshop on read-across concepts in toxicology.
  • Read-across is a method used to predict the properties of a chemical substance based on data from structurally similar substances.

Purpose of the Study:

  • To provide an overview of general read-across concepts and their application in toxicology.
  • To discuss the development and use of algorithms for assessing chemical similarity relevant to specific toxicological endpoints.
  • To highlight the importance of kinetics, metabolism, and new approach methods in enhancing read-across reliability.

Main Methods:

  • Discussion of chemical similarity algorithms based on molecular descriptors and weighting schemata.
  • Integration of toxicokinetic and metabolic considerations into read-across assessments.
  • Application of new approach methods, such as plasma metabolomics in rats.
  • Utilization of in silico tools and large structure-activity relationship (SAR) datasets for toxicity prediction.

Main Results:

  • Algorithms that adapt to data and distinguish between similar/dissimilar molecules for specific endpoints are crucial.
  • Read-across cases require attention to kinetics and metabolism for success.
  • New approach methods and in silico tools demonstrate high predictivity for certain toxicity endpoints.
  • Automated processes can assess chemical-activity spaces around target substances.

Conclusions:

  • The workshop provided current criteria for effective read-across in toxicology.
  • Future developments in read-across will leverage advanced computational tools and integrated biological data.
  • Read-across is a valuable tool for chemical safety assessment, with ongoing advancements improving its predictive power.