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Updated: Dec 18, 2025
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
975
Multidisciplinary care in Stevens-Johnson syndrome
Swapna S Shanbhag1, James Chodosh1, Cherie Fathy2
1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Therapeutic Advances in Chronic Disease
|June 12, 2020
Summary
Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) can affect multiple organ systems beyond the skin. Early recognition and management of these rare but severe reactions are crucial for preventing chronic complications.
Area of Science:
- Dermatology
- Internal Medicine
- Critical Care Medicine
Background:
- Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe, potentially fatal mucocutaneous diseases.
- Non-cutaneous organ involvement in SJS/TEN is often underrecognized, leading to suboptimal clinical management.
- Improving supportive care reduces mortality, increasing the prevalence of chronic complications.
Purpose of the Study:
- To review organ system involvement in SJS/TEN.
- To provide an overview of SJS/TEN management strategies.
- To propose essential discharge communication points for patients and families.
Main Methods:
- Literature review of SJS/TEN manifestations and management.
- Discussion of organ systems including pulmonary, gastrointestinal/hepatic, and renal.
- Inclusion of psychosocial, nutritional, and pain management aspects.
Main Results:
- SJS/TEN can affect pulmonary, GI/hepatic, oral, ENT, gynecologic, GU, and renal systems.
- Management strategies for acute and chronic complications are discussed.
- Key discharge information for long-term patient care is outlined.
Conclusions:
- Comprehensive understanding of SJS/TEN organ involvement is vital for acute care.
- Proactive management of acute manifestations can mitigate chronic sequelae.
- Effective patient/family communication upon discharge is essential for managing long-term consequences.
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