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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Exercise plus caloric restriction lowers soluble RAGE in adults with chronic kidney disease

Steven K Malin1,2,3, Sankar D Navaneethan4, Ciaran E Fealy5

  • 1Department of Kinesiology University of Virginia Charlottesville VA USA.

Obesity Science & Practice
|June 12, 2020
PubMed
Abstract

Insights

Lifestyle intervention including exercise and caloric restriction effectively lowered soluble RAGE in patients with chronic kidney disease (CKD). This approach improved glucose regulation and insulin sensitivity, offering a promising strategy for managing CKD complications.

Area of Science:

  • Nephrology
  • Metabolic Syndrome
  • Exercise Physiology

Background:

  • Chronic kidney disease (CKD) incidence is rising, linked to obesity, diabetes, and cardiovascular disease.
  • Elevated soluble RAGE (sRAGE) is implicated in CKD pathogenesis via pro-inflammatory pathways.
  • Lifestyle interventions may mitigate inflammation and improve outcomes in CKD patients.

Purpose of the Study:

  • To investigate the effect of a 12-week lifestyle intervention on soluble RAGE (sRAGE) levels in adults with CKD.
  • To determine if exercise and caloric restriction can reduce sRAGE and improve metabolic markers.

Main Methods:

  • Pilot study involving 8 adults with CKD undergoing supervised aerobic exercise and dietary counseling.
  • Measurements included body composition, aerobic fitness (VO2max), insulin sensitivity, and plasma sRAGE and fetuin-A.
  • Intervention involved 12 weeks of exercise (5 d/wk) and low-fat diet counseling.

Main Results:

  • The lifestyle intervention significantly decreased plasma sRAGE levels (P = .02).
  • Reductions in sRAGE were associated with improved 2-hour blood glucose (r = 0.76, P = .03) and increased insulin sensitivity (r = -0.90, P < .01).
  • Exercise also improved body weight, fasting glucose, VO2max, and insulin sensitivity (all P < .05).

Conclusions:

  • Combined exercise and caloric restriction effectively lower sRAGE in CKD patients.
  • This intervention improves glucose regulation and insulin sensitivity, suggesting a role in managing CKD.
  • Lifestyle modification is a viable strategy for reducing inflammation and improving metabolic health in CKD.
Keywords:
cardiometabolic riskinsulin sensitivitytype 2 diabetes

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