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Papillary Thyroid Carcinoma in Paediatric Age
A Garzi1, M Prestipino2, E Calabrò1
1Division of Pediatric M.I.S. and Robotic Surgery University of Salerno, Italy.
Translational Medicine @ Unisa
|June 12, 2020
Summary
Differentiated thyroid carcinoma in children is rare but treatable with early diagnosis. Total thyroidectomy is the recommended treatment, potentially followed by lymph node removal and radioiodine therapy to minimize relapse risk.
Area of Science:
- Pediatric Endocrinology
- Oncology
- Surgical Oncology
Background:
- Differentiated thyroid carcinoma (DTC) is uncommon in children.
- Early diagnosis is challenging due to subtle clinical presentation but crucial for effective treatment.
- Risk factors and family history are not always present in pediatric DTC cases.
Purpose of the Study:
- To describe three pediatric cases of papillary thyroid carcinoma (PTC).
- To highlight diagnostic methods and therapeutic strategies for pediatric DTC.
- To emphasize the importance of total thyroidectomy in managing pediatric DTC.
Main Methods:
- Case series of three children diagnosed with papillary thyroid carcinoma.
- Diagnostic tools included fine-needle aspiration, lymph node biopsy, ultrasound, and imaging.
- Treatment involved total thyroidectomy, with lymph node exeresis and radioiodiotherapy in select cases.
Main Results:
- Two cases presented as asymptomatic neck swellings; one presented with persistent lateral cervical lymphadenopathy.
- Diagnosis was confirmed via fine-needle aspiration or lymph node biopsy.
- All patients underwent total thyroidectomy; two required lymph node dissection due to metastasis.
Conclusions:
- Total thyroidectomy is the optimal primary treatment for pediatric differentiated thyroid carcinoma.
- Subsequent lymph node exeresis and radioiodiotherapy may be necessary based on metastatic spread.
- Complete gland removal significantly reduces the risk of disease recurrence in children.
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