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Updated: Dec 18, 2025
09:22
Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
Published on: May 12, 2020
5.9K
[Treatment refractory multidrug-resistant bacterial keratitis]
Florian Schubert1, Walter Sekundo2, Christoph Paul2
1Klinik für Augenheilkunde, UKGM GmbH, Standort Marburg, Baldingerstr., 35043, Marburg, Deutschland. Florian.Schubert@uk-gm.de.
Summary
Severe infectious keratitis resistant to treatment was successfully managed. A multidrug-resistant Pseudomonas aeruginosa was identified and treated with specific antibiotics based on sensitivity testing.
Area of Science:
- Ophthalmology
- Microbiology
Background:
- Infectious keratitis can be severe and difficult to treat.
- Identifying the causative pathogen is crucial for effective treatment.
Observation:
- A case of severe infectious keratitis unresponsive to initial treatments is presented.
- Multiple corneal and anterior chamber samples were initially negative for pathogens.
Findings:
- A multidrug-resistant Pseudomonas aeruginosa strain was ultimately isolated.
- Treatment with tobramycin and amikacin, guided by antibiotic sensitivity, led to successful resolution.
Implications:
- Multidrug-resistant pathogens should be considered in refractory infectious keratitis.
- Aggressive sampling and antibiotic sensitivity testing are vital for optimal patient outcomes.
- This case highlights the importance of considering resistant organisms in severe ocular infections.
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