Related Experiment Video

Updated: Dec 18, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

10.0K

Sonic hedgehog signaling pathway in Myelodysplastic Syndrome: Abnormal activation and jervine intervention

YuTing Qin1, Ming Jiang1, Nilupar Tuerxung1

  • 1Hematologic Disease Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Xinshi District, Urumqi, Xinjiang Province 830054, China.

Gene
|June 12, 2020
PubMed
Abstract

Insights

The Sonic hedgehog (Shh) signaling pathway is activated in Myelodysplastic Syndrome (MDS). Inhibiting this pathway with jervine shows potential as a therapeutic strategy for MDS patients.

Area of Science:

  • Hematology
  • Molecular Biology
  • Oncology

Background:

  • Myelodysplastic Syndrome (MDS) is a group of clonal hematopoietic stem cell disorders.
  • The Sonic hedgehog (Shh) signaling pathway plays a role in various cellular processes, including development and disease.

Purpose of the Study:

  • To investigate the role of the Shh signaling pathway in MDS occurrence and progression.
  • To evaluate jervine as a potential therapeutic agent for MDS by targeting the Shh pathway.

Main Methods:

  • Analysis of Shh pathway components (Shh, Smo, Ptch-1, Gli-1) in bone marrow CD34+ cells from MDS patients using RT-qPCR.
  • Correlation analysis of Shh pathway gene expression with clinical features and prognosis.
  • Assessment of jervine's effects on MUTZ-1 cell proliferation, apoptosis, cell cycle, and Shh pathway gene/protein expression.

Main Results:

  • Significantly increased expression of Shh, Gli-1, and Smo in MDS patients.
  • Correlation of Smo and Gli-1 expression with chromosome karyotype and IPSS, indicating a link to poor prognosis.
  • Jervine inhibited Shh pathway gene/protein expression, suppressed proliferation, promoted apoptosis, and arrested the cell cycle in MUTZ-1 cells.

Conclusions:

  • Abnormal activation of the Shh signaling pathway is implicated in MDS pathogenesis.
  • Jervine demonstrates potential as a therapeutic strategy for MDS by modulating the Shh pathway.
Keywords:
JervineMyelodysplastic SyndromeSonic hedgehog signaling pathway

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