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Updated: Dec 18, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Naturally potential antiviral agent polysaccharide from Dendrobium nobile Lindl
Zhurui Li1, Jie Xiang1, Deyu Hu1
1State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering/Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.
Abstract:
A polysaccharide DNPE6(11) was purified from Dendrobium nobile Lindl. (D. nobile Lindl.). Its structural characteristic, antiviral activity, and preliminary mechanism were studied. The structural characteristic analysis indicated that DNPE6(11) was a novel homogenous heteropolysaccharide from D. nobile Lindl. Bioactivity assays indicated that DNPE6(11) possessed outstanding curative and inactivating activities against cucumber mosaic virus, which were superior to chitosan oligosaccharide and lentinan. Additionally, DNPE6(11) exhibited notable protective activity against potato virus Y, which was better than Ningnanmycin. Furthermore, the preliminary mechanism study found that DNPE6(11) cannot accumulate salicylic acid to induce systemic acquired resistance, but had a strong binding capacity for cucumber mosaic virus coat protein. Therefore, DNPE6(11) could be considered as a promising antiviral agent to study in the future.
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