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[The RAAS and SARS-CoV-2: A riddle to solve]

M Choi1, E A Aiello1, I L Ennis1

  • 1Sociedad Argentina de Hipertensión Arterial (SAHA), CONICET, CABA, Argentina.

Hipertension Y Riesgo Vascular
|June 13, 2020
PubMed

Insights

The renin-angiotensin-aldosterone system (RAAS) inhibitors may be associated with SARS-CoV-2 infection. Further research is needed to understand this evolving topic in COVID-19.

Area of Science:

  • Infectious Diseases
  • Cardiovascular Pharmacology

Background:

  • COVID-19 emerged in late 2019, sparking global health concerns.
  • The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in cardiovascular and renal function.
  • A potential link between RAAS inhibitors and SARS-CoV-2 infection has been debated.

Purpose of the Study:

  • To review current knowledge on the association between RAAS inhibitors and SARS-CoV-2 infection.
  • To inform health professionals about the evolving evidence regarding this interaction.
  • To consolidate findings from pre-clinical and clinical studies.

Main Methods:

  • Review of pre-clinical studies investigating the link between coronavirus and RAAS.
  • Analysis of clinical studies examining the association between antihypertensive therapy and SARS-CoV-2 infection.
  • Synthesis of existing evidence to provide a current state of knowledge.

Main Results:

  • Pre-clinical studies suggest a biological link between the RAAS and coronavirus.
  • Clinical evidence on the association between RAAS inhibitors and SARS-CoV-2 infection is still evolving and debated.
  • The precise impact of RAAS inhibitors on COVID-19 outcomes requires further investigation.

Conclusions:

  • The relationship between RAAS inhibitors and SARS-CoV-2 infection is complex and warrants ongoing research.
  • Health professionals should stay updated as new evidence emerges on this topic.
  • Further studies are recommended to clarify the clinical implications for patients on RAAS-inhibiting therapies.

Keywords:
Angiotensin receptor blockerAngiotensin-converting enzyme inhibitorsAntagonistas del receptor de angiotensina IIHigh blood pressureHipertensión arterialInhibidores de la enzima convertidora de angiotensinaRenin-angiotensin-aldosterone systemSARS-CoV-2Sistema renina-angiotensina-aldosterona

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