Related Experiment Video
Updated: Dec 18, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3.2K
[The RAAS and SARS-CoV-2: A riddle to solve]
M Choi1, E A Aiello1, I L Ennis1
1Sociedad Argentina de Hipertensión Arterial (SAHA), CONICET, CABA, Argentina.
Hipertension Y Riesgo Vascular
|June 13, 2020
Summary
The renin-angiotensin-aldosterone system (RAAS) inhibitors may be associated with SARS-CoV-2 infection. Further research is needed to understand this evolving topic in COVID-19.
Area of Science:
- Infectious Diseases
- Cardiovascular Pharmacology
Background:
- COVID-19 emerged in late 2019, sparking global health concerns.
- The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in cardiovascular and renal function.
- A potential link between RAAS inhibitors and SARS-CoV-2 infection has been debated.
Purpose of the Study:
- To review current knowledge on the association between RAAS inhibitors and SARS-CoV-2 infection.
- To inform health professionals about the evolving evidence regarding this interaction.
- To consolidate findings from pre-clinical and clinical studies.
Main Methods:
- Review of pre-clinical studies investigating the link between coronavirus and RAAS.
- Analysis of clinical studies examining the association between antihypertensive therapy and SARS-CoV-2 infection.
- Synthesis of existing evidence to provide a current state of knowledge.
Main Results:
- Pre-clinical studies suggest a biological link between the RAAS and coronavirus.
- Clinical evidence on the association between RAAS inhibitors and SARS-CoV-2 infection is still evolving and debated.
- The precise impact of RAAS inhibitors on COVID-19 outcomes requires further investigation.
Conclusions:
- The relationship between RAAS inhibitors and SARS-CoV-2 infection is complex and warrants ongoing research.
- Health professionals should stay updated as new evidence emerges on this topic.
- Further studies are recommended to clarify the clinical implications for patients on RAAS-inhibiting therapies.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
6.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.0K
02:50Conjugated Proteins
25.6K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
25.6K
00:57Viral Recombination
24.7K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
24.7K
01:05Single Nucleotide Polymorphisms-SNPs
17.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.7K
01:29Viruses with RNA Genomes
576
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
576
01:20The JAK-STAT Signaling Pathway
11.4K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.4K