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Endocrine changes in SARS-CoV-2 patients and lessons from SARS-CoV
Shubham Agarwal1, Sanjeev Kumar Agarwal2
1Department of Internal Medicine, Rosalind Franklin University of Medicine and Science Chicago Medical School, North Chicago, Illinois, USA shubhamagarwaldr@gmail.com.
Postgraduate Medical Journal
|June 13, 2020
Summary
This review highlights endocrine dysfunctions in patients with severe acute respiratory syndrome (SARS) and SARS-CoV-2 infections. Understanding these hormonal imbalances is crucial for managing COVID-19 complications and mortality.
Area of Science:
- Endocrinology
- Virology
- Pathology
Background:
- Coronavirus outbreaks, including SARS and COVID-19, cause significant mortality.
- Patient deaths often result from complications beyond viral spread, including endocrine disturbances.
- Endocrine involvement in SARS was noted, with some derangements persisting post-recovery.
Purpose of the Study:
- To review and synthesize reported endocrine changes in SARS-CoV and SARS-CoV-2 infections.
- To emphasize the importance of addressing endocrine disturbances in managing coronavirus disease.
- To explore the role of endocrine dysfunctions in predicting and contributing to patient mortality.
Main Methods:
- Literature review focusing on endocrine and biochemical changes in SARS and COVID-19 patients.
- Analysis of reported clinical presentations and pathological mechanisms.
- Synthesis of findings related to endocrine gland involvement and patient outcomes.
Main Results:
- Both SARS-CoV and SARS-CoV-2 infections are associated with various endocrine system dysfunctions.
- These endocrine changes can manifest during illness, convalescence, and even after recovery.
- Endocrine disturbances are increasingly recognized as significant factors in patient mortality.
Conclusions:
- Endocrine complications are a critical, often overlooked, aspect of coronavirus infections.
- Addressing these hormonal imbalances is imperative for improving patient outcomes and reducing mortality in pandemics.
- Further research into the mechanisms and management of endocrine dysfunctions in COVID-19 is warranted.
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