Transient Brugada Pattern Induced by Loperamide Abuse
Ali Atoot1, Scott Sholem2, Ibrahim Khaddash3
1Anesthesiology, Hackensack University Medical Center, Hackensack, USA.
Cureus
|June 13, 2020
Summary
Brugada syndrome, a genetic heart condition, can be mimicked by loperamide abuse. This case highlights a young man who experienced a temporary Brugada pattern due to abusing this medication.
Area of Science:
- Cardiology
- Clinical Electrophysiology
- Pharmacology
Background:
- Brugada syndrome (BrS) is a genetically determined arrhythmic disorder.
- It is characterized by syncope or sudden cardiac death in individuals with structurally normal hearts.
- An electrocardiogram (ECG) is crucial for diagnosis.
Observation:
- Loperamide abuse is an exceedingly rare cause of ECG patterns mimicking BrS.
- This case report details a transient Brugada pattern.
- The pattern was observed in a young, healthy male.
Findings:
- Loperamide abuse can induce a Brugada ECG pattern.
- The induced Brugada pattern in this case was transient.
- This highlights a rare iatrogenic cause of a potentially malignant ECG presentation.
Implications:
- Awareness of loperamide's potential cardiotoxicity is crucial for clinicians.
- This case underscores the importance of thorough medication history in patients presenting with unexplained ECG abnormalities.
- Further research into the mechanisms of loperamide-induced cardiotoxicity is warranted.
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