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Citius, Altius, Fortius
Proteins
|June 13, 2020
Summary
Macromolecular structures, like athletes, push biological limits. Analysis of the Protein Data Bank (PDB) reveals that while many macromolecular structures are consistent, some records are continually broken, challenging assumptions of biological limits.
Area of Science:
- Structural Biology
- Biophysics
- Biochemistry
Background:
- The concept of limits in human athletic performance is often debated.
- Parallels exist between athletic achievements and the structural integrity of macromolecules.
Purpose of the Study:
- To investigate the concept of 'records' and limits in macromolecular structures.
- To challenge the notion that macromolecular structures exhibit only minor variations around a constant value.
Main Methods:
- Analysis of data within the Protein Data Bank (PDB).
- Comparison of structural validation and re-refinement data for macromolecules.
Main Results:
- The Protein Data Bank (PDB) data contradicts the idea that macromolecular structures have highly conserved properties.
- Evidence suggests that, similar to athletic records, some macromolecular structural parameters are continually being 'broken' or improved upon.
Conclusions:
- Macromolecular structures exhibit a wider range of variation than previously assumed.
- The pursuit of 'records' in macromolecular structure refinement is analogous to athletic endeavors, pushing the boundaries of biological possibility.
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