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Mitochondriotropic lanthanide nanorods: implications for multimodal imaging.

Harwinder Singh1, Sreejesh Sreedharan, Esteban Oyarzabal

  • 1Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India. sumitpramanik@csmcri.res.in.

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Summary

We developed novel lanthanide nanorods for high-resolution fluorescence imaging and dual-mode magnetic resonance imaging. These mitochondriotropic nanorods offer advanced capabilities for biological and medical research.

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Area of Science:

  • Nanotechnology
  • Biomedical Imaging
  • Materials Science

Background:

  • Mitochondria are crucial cellular organelles targeted in various diseases.
  • High-resolution imaging techniques are vital for understanding cellular processes.
  • Lanthanide-based nanomaterials offer unique optical and magnetic properties.

Purpose of the Study:

  • To synthesize and characterize two-photon active, mitochondriotropic lanthanide nanorods.
  • To evaluate their utility for high-resolution fluorescence imaging.
  • To assess their potential as dual-mode contrast agents for magnetic resonance imaging (MRI).

Main Methods:

  • Synthesis of lanthanide nanorods incorporating Gadolinium (Gd).
  • Two-photon excitation fluorescence microscopy for cellular imaging.
  • T1-T2 dual-mode MRI contrast agent evaluation in mouse brain models.

Main Results:

  • Successfully synthesized mitochondriotropic lanthanide nanorods with two-photon activity.
  • Achieved high-resolution fluorescence imaging of mitochondria within cells.
  • Demonstrated the material's efficacy as a T1-T2 dual-mode MRI contrast agent for mouse brains.

Conclusions:

  • Lanthanide nanorods are effective tools for advanced cellular and in vivo imaging.
  • The dual-mode imaging capability offers versatile applications in biomedical research.
  • Mitochondriotropic targeting enhances specificity for cellular studies.