Related Experiment Video
Updated: Dec 18, 2025
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Urinary Intestinal Fatty Acid Binding Protein for Diagnosis of Necrotizing Enterocolitis
Amarnath Saran1, Devananda Devegowda2, Srinivasa Murthy Doreswamy3
1Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
Objective:
This study was conducted to compare the urinary levels of intestinal fatty acid binding protein (I-FABP) and I-FABP: Cr (creatinine) between neonates with necrotising enterocolitis and gestation matched healthy controls.
Methods:
24 neonates with stage 1, 25 with stage 2 and 3 necrotizing enterocolitis, and 25 gestation matched (32.9 wk) controls were compared. Single spot urine sample was collected for estimating the IFABP and creatinine levels.
Results:
Median (IQR) value of urinary I-FABP were higher in those with stage 2, 3 NEC [2773 (2417.7- 2820)] than stage 1 NEC [1164 pg/mL (1341.5 - 2213.4)] and controls [413 (113 - 729.7); pg/mL] (P<0.001). Urinary I-FABP: Cr levels of 3.6 pg/mmoL had a sensitivity and specificity of 96% and 99.5%, respectively in diagnosing stage 2/3 NEC.
Conclusion:
Urinary IFABP: Creatine ratio of 3.6 pg/mmoL is highly specific for stage 2 and 3 NEC.
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