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Updated: Dec 18, 2025
10:42
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
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The microbiome in pediatric oncology
Seth J Rotz1, Christopher E Dandoy2
1Department of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, Cleveland Clinic Children's Hospital, Cleveland, Ohio.
Cancer
|June 14, 2020
Summary
The human microbiome influences pediatric cancer by affecting infections and immune responses. Further research is needed to understand and potentially modulate these microbial communities for better outcomes.
Area of Science:
- Microbiology
- Pediatric Oncology
- Immunology
Background:
- The human microbiome, a collection of microorganisms, is crucial for metabolism and host defense.
- Next-generation sequencing enhances understanding of microbial diversity.
- The microbiome's role in pediatric hematology/oncology is an emerging area of research.
Purpose of the Study:
- To review the evidence on the microbiome's role in pediatric hematology/oncology.
- To discuss potential methods for modulating the microbiome.
- To identify key areas for future research.
Main Methods:
- Literature review of existing studies.
- Examination of evidence linking microbiome to pediatric cancer.
- Discussion of microbiome modulation strategies.
Main Results:
- The microbiome impacts susceptibility to infections in pediatric cancer patients.
- Microbial communities influence immune responses to cancer.
- Chemotherapy and antibiotics alter the microbiome with unknown effects.
Conclusions:
- The microbiome plays a significant role in pediatric hematology/oncology.
- Understanding microbiome modulation could offer therapeutic benefits.
- Further investigation is essential to elucidate specific mechanisms and applications.
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