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Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

Yujiao Zhang1, Xiaoyuan Zeng1, Yingying Jiao1

  • 1Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Thrombosis Research
|June 15, 2020
PubMed

Insights

This review examines hematological changes in COVID-19 patients, focusing on thrombocytopenia. Understanding these platelet count changes is crucial for predicting disease severity and patient outcomes.

Area of Science:

  • Hematology
  • Virology
  • Infectious Diseases

Background:

  • COVID-19, caused by SARS-CoV-2, shares clinical similarities with SARS and MERS.
  • Hematological alterations, including lymphopenia and thrombocytopenia, are observed in COVID-19 patients.
  • Thrombocytopenia affects 5-41.7% of COVID-19 cases, indicating its clinical significance.

Purpose of the Study:

  • To summarize hematological changes in SARS-CoV-2 infected individuals.
  • To explore potential mechanisms behind thrombocytopenia development in COVID-19 patients.

Main Methods:

  • Review of existing literature on COVID-19 and hematological findings.
  • Analysis of reported cases and clinical studies concerning SARS-CoV-2 infection.

Main Results:

  • Common hematological changes include lymphopenia and thrombocytopenia.
  • Platelet count dynamics may offer prognostic value in COVID-19.
  • Mechanisms driving thrombocytopenia in COVID-19 require further investigation.

Conclusions:

  • Hematological changes are a notable feature of COVID-19.
  • Further research is needed to fully understand and address thrombocytopenia in COVID-19 patients.

Keywords:
COVID-19SARS-CoV-2Thrombocytopenia

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