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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
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LSEC model of aging.

Laurent Grosse1, Dmitry V Bulavin1

  • 1Institute for Research on Cancer and Aging of Nice (IRCAN), INSERM, Université Côte d'Azur, CNRS, Nice, France.

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|June 15, 2020
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Summary
This summary is machine-generated.

Senescent liver cells (LSECs) accumulate with age, initially clearing toxins but later failing, potentially shortening lifespan. Targeting LSEC senescence may extend longevity.

Keywords:
aginglifespanliver sinusoid endothelial cellssenescencee

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Area of Science:

  • Cellular senescence
  • Aging research
  • Endothelial cell biology

Background:

  • p16High senescent cells are implicated in aging and age-related diseases.
  • Accumulation of senescent liver sinusoid endothelial cells (LSECs) expressing p16 is observed in aging mice.
  • Early-stage senescent LSECs exhibit enhanced detoxification of macromolecules like oxidized LDL (oxLDL).

Purpose of the Study:

  • To investigate the role of LSEC senescence in aging and longevity.
  • To understand the functional decline of senescent LSECs over time.
  • To explore potential strategies for lifespan extension by targeting LSEC senescence.

Main Methods:

  • Analysis of aging mouse models.
  • Assessment of senescence markers in LSECs.
  • Evaluation of LSEC function in toxin clearance.
  • Investigation of molecular mechanisms underlying functional decline.

Main Results:

  • Aging mice show progressive accumulation of p16High senescent LSECs.
  • Senescent LSECs initially enhance, then decline in, their ability to clear toxins.
  • Functional decline is linked to increased endothelial thickness and reduced scavenger receptor/endocytosis gene expression.
  • Impaired detoxification may contribute to mortality, exacerbated by age-related intestinal leakiness.

Conclusions:

  • LSEC senescence may act as an endogenous aging clock regulating lifespan.
  • The decline in LSEC detoxification function is a critical factor in aging.
  • Targeting LSEC senescence presents a potential therapeutic avenue for extending lifespan.