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Updated: Dec 18, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Epilepsy surgery in tuberous sclerosis complex (TSC): emerging techniques and redefinition of treatment goals
Jeffrey M Treiber1,2, Daniel J Curry1,2, Howard L Weiner3,4
1Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Abstract:
Epilepsy occurs in nearly all patients with tuberous sclerosis and is often refractory to medical treatment. The definition of surgical candidacy in these patients has broadened in recent years due to philosophical and technological advances. The goals of surgery have shifted to focusing on quality of life and maximizing neurodevelopmental potential in patients unable to obtain seizure freedom. Novel diagnostic, ablative, and neuromodulatory techniques have been developed that may help patients that were previously considered inoperable to have an improved quality of life. In the coming years, it is expected that these techniques will be further refined and lead to an improvement of neurological prognosis in patients with tuberous sclerosis.
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