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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
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[Correlation between elevation of brachial artery pulse pressure increased and coronary heart disease in different

Y Q Si1, Z J Ding1, W F Wang1

  • 1Department of Cardiology, the Affiliated Hospital of Chengde Medical College, Chengde Cardiovascular Institute, Chengde 067000, China.

Zhonghua Yi Xue Za Zhi
|June 16, 2020
PubMed

Insights

Elevated brachial pulse pressure is an independent risk factor for coronary heart disease (CHD). This risk is significantly higher in women than in men, suggesting pulse pressure as a potential new biomarker for CHD.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Epidemiology

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Identifying novel risk factors is crucial for effective prevention and management strategies.
  • Brachial pulse pressure (PP) is a measure of arterial stiffness and cardiovascular risk.

Purpose of the Study:

  • To investigate the association between elevated brachial pulse pressure and the prevalence of CHD.
  • To determine if brachial pulse pressure is an independent risk factor for CHD in different genders.
  • To compare the risk of elevated brachial pulse pressure for CHD between males and females.

Main Methods:

  • A cohort of 5,116 inpatients with suspected stable coronary heart disease were analyzed.
  • Patients were divided into CHD and non-CHD groups based on clinical data.
  • Binary logistic regression models were used to assess risk factors, including elevated pulse pressure, stratified by gender.

Main Results:

  • Elevated pulse pressure was significantly more prevalent in the CHD group compared to the non-CHD group (P<0.05).
  • Elevated pulse pressure was identified as an independent risk factor for CHD in both males and females (P<0.05).
  • The risk of CHD associated with elevated pulse pressure was significantly higher in females (OR: 1.741) than in males (OR: 1.284).

Conclusions:

  • Elevated brachial pulse pressure is a significant independent risk factor for coronary heart disease.
  • The association between elevated pulse pressure and CHD risk is stronger in women than in men.
  • Pulse pressure may serve as a valuable, novel biomarker for assessing CHD risk, particularly in female populations.

Keywords:
Coronary heart diseaseDiagnosisPulse pressureRisk factor

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