Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Type IV Collagen of Basal Lamina

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...

Fibril-associated Collagen

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...

Nephrotic Syndrome III : Nursing Management

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pectoral Nerve Block for Cardiac Device Implants: A Systematic Review and Meta-Analysis.

Pacing and clinical electrophysiology : PACE·2026

Same author

High-performance graphene wearable THz nano-antenna using a metasurface reflector: dual-band, dual-port, and low-SAR operation.

Applied optics·2026

Same author

Proarrhythmia owing to altered ventricular activation sequence in a patient with a permanent pacemaker.

HeartRhythm case reports·2025

Same author

Beyond the beats: exploring the link between blood pressure fluctuations with anxiety, depression, and sleep.

Frontiers in psychiatry·2025

Same author

Role of Vaginal and Gut Microbiota in Human Papillomavirus (HPV) Progression and Cervical Cancer: A Systematic Review of Microbial Diversity and Probiotic Interventions.

Cureus·2025

Same author

Abnormal automaticity in a left-sided free wall accessory pathway - an unusual form of preexcitation.

HeartRhythm case reports·2024

Search research articles

Related Experiment Video

Updated: Dec 18, 2025

Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models

Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models

Published on: March 21, 2025

Collagenofibrotic Glomerulopathy: Report a Rare Case.

Rakesh Agarwal¹, Rashmi Baid², Jotideb Mukhopadhyay¹

¹Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, India.

Archives of Iranian Medicine

|June 16, 2020

Summary

Collagenofibrotic glomerulopathy, a rare kidney disease, was diagnosed in an adult with nephrotic syndrome and intestinal villous atrophy. This case highlights a potential new extra-renal manifestation of this condition.

Keywords:

Collaagenofibrotic glomerulopathy Nephrotic syndrome

More Related Videos

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

Published on: September 20, 2012

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools

Published on: November 11, 2020

Related Experiment Videos

Last Updated: Dec 18, 2025

Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models

Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models

Published on: March 21, 2025

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

Published on: September 20, 2012

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools

Published on: November 11, 2020

Area of Science:

Nephrology
Pathology
Gastroenterology

Background:

Collagenofibrotic glomerulopathy (CFG) is a rare kidney disease characterized by collagen type III deposition.
Fewer than 40 cases of CFG have been reported globally, often presenting with nephrotic syndrome.
Extra-renal manifestations like hypertension and anemia are documented, but gastrointestinal involvement is not.

Observation:

This report details a unique case of adult-onset nephrotic syndrome.
The patient also presented with partial villous atrophy of the intestine.
Diagnosis confirmed CFG with subendothelial and mesangial collagen type III deposition.

Findings:

The case presents collagenofibrotic glomerulopathy (CFG) with associated partial villous atrophy.
This represents a previously unreported extra-renal manifestation of CFG.
Elevated procollagen III peptide levels were noted, consistent with CFG.

Implications:

This case expands the known clinical spectrum of collagenofibrotic glomerulopathy.
It suggests a potential link between CFG and gastrointestinal pathology, specifically villous atrophy.
Further research is warranted to investigate this association and its underlying mechanisms.