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Updated: Dec 18, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics.

Verena B K Kunig1, Marco Potowski1, Mohammad Akbarzadeh2

  • 1TU Dortmund University, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.

Angewandte Chemie (International Ed. in English)
|June 16, 2020
PubMed
Summary

Researchers created a DNA-encoded peptoid library using tryptophan mimics to discover new protein inhibitors. This method identified inhibitors for MDM2 and a novel class targeting TEAD-YAP interactions, impacting gene expression.

Keywords:
DNA-encoded libraryUgi reactioncombinatorial chemistrypeptidomimeticsprotein-protein interaction inhibition

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