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Planar Chirality Directs Enantiospecific Diastereoselectivity in Isocyanide-Based Multicomponent Reactions

Michael Kapsalis1, Michael Fragkiadakis1, Iakovos Konstantaras1

  • 1Chemistry Department, University of Crete, Voutes, 70013 Heraklion, Greece.

ACS Organic & Inorganic Au
|August 8, 2026
PubMed
Summary

Planar chirality in [2.2]-paracyclophane scaffolds provides predictable stereochemical control in isocyanide-based multicomponent reactions. This substrate-controlled approach achieves enantiospecific transfer without external chiral catalysts.

Keywords:
[2.2]Paracyclophanesdiastereoselectivitymulticomponent reactionspasserini reactionplanar chiralityugi reaction

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