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Updated: Dec 18, 2025
Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
A synthetic guide to alkynyl sulfides.
Jeffrey Santandrea1, Eric Godin1, Shawn K Collins1
1Department of Chemistry and Centre in Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, CanadaH3C 3J7. shawn.collins@umontreal.ca.
Alkynyl sulfides are versatile building blocks for chemical synthesis. This review surveys and evaluates methods for their formation, highlighting advantages and limitations of current technologies.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Alkynyl sulfides are valuable synthons due to their stability and reactivity.
- Traditional methods for alkynyl sulfide synthesis include dehydrohalogenation approaches.
Purpose of the Study:
- To survey and evaluate existing methods for alkynyl sulfide synthesis.
- To provide an overview of the advantages and limitations of current technologies for forming Csp-S bonds.
Main Methods:
- Review of literature on alkynyl sulfide synthesis.
- Analysis of methods including umpolung strategies, nucleophilic and electrophilic thiol alkynylation, and catalytic approaches.
Main Results:
- Recent synthetic strategies focus on catalysis and expanding reaction scope.
- Umpolung strategies and thiol alkynylation offer alternative routes to alkynyl sulfides.
Conclusions:
- A comprehensive understanding of current alkynyl sulfide synthesis methods is crucial for advancing organic transformations.
- The development of novel catalytic methods continues to expand the accessibility and utility of alkynyl sulfides.
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02:26Preparation and Reactions of Sulfides
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