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Adenoviruses - Infection, pathogenesis and therapy
1Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
FEBS Letters
|June 16, 2020
Summary
Adenoviruses (AdVs) are DNA viruses impacting human health and advancing life sciences. This collection explores AdV molecular biology, genetics, and their use in gene therapy, highlighting knowledge gaps.
Area of Science:
- Virology
- Molecular Cell Biology
- Structural Biology
- Genetics
- Immunology
- Gene Therapy
- Epidemiology
Background:
- Adenoviruses (AdVs) are nonenveloped DNA viruses affecting vertebrates, including humans, with a 67-year research history.
- AdVs cause disease but have also significantly advanced life sciences and medicine.
- Recent applications include AdVs as vehicles in gene therapy and vaccination strategies.
Discussion:
- This special issue compiles 23 review articles by leading adenovirologists, offering a comprehensive overview.
- The collection covers diverse aspects of AdV research, from molecular mechanisms to epidemiological impact.
- A critical discussion identifies six key 'blind spots' or underexplored areas in adenovirology.
Key Insights:
- AdVs provide fundamental insights into virus-host interactions at cellular, tissue, and organismal levels.
- Their role extends to understanding systems and metabolic networks influenced by viral infections.
- The reviewed articles offer a solid foundation for exploring the rich heritage of AdV research.
Outlook:
- Future research directions are suggested by identifying knowledge gaps in adenovirology.
- Continued exploration of AdVs promises further advancements in medicine and biotechnology.
- Understanding AdV biology is crucial for developing effective countermeasures and therapeutic applications.
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