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Testosterone: Functions and Regulation

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...

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A Dozen Testosterone Samples From One Patient, on One Day?

Kevin F Foley¹

¹Department of Pathology, Kaiser Permanente Northwest, Portland, Oregon.

Laboratory Medicine

|June 16, 2020

Summary

This summary is machine-generated.

Diagnosing female virilization and infertility is aided by lab tests. Ovarian vein sampling successfully located bilateral androgen production in a patient with elevated testosterone, amenorrhea, and hirsutism.

Keywords:

cortisol oophorectomy ovarian sampling testosterone tumor

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Area of Science:

Endocrinology
Reproductive Medicine
Medical Diagnostics

Background:

Female virilization and infertility present diagnostic challenges.
Routine laboratory testing aids in differential diagnosis.
Elevated serum testosterone is a key indicator.

Observation:

A 28-year-old female presented with amenorrhea, hirsutism, and infertility.
Markedly elevated serum testosterone levels were detected.
Bilateral ovarian vein sampling was performed for testosterone localization.

Findings:

Ovarian vein sampling proved diagnostic in localizing ectopic testosterone production.
Bilateral androgen production was identified in this unique case.
This highlights the utility of ovarian vein sampling when adrenal vein sampling is insufficient.

Implications:

Accurate localization of androgen excess is crucial for guiding surgical interventions.
Interdisciplinary collaboration between clinical laboratories and procedural teams is essential.
This case expands understanding of rare causes of virilization and infertility.