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Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes
Published on: November 21, 2017
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Developments in Photoredox/Nickel Dual-Catalyzed 1,2-Difunctionalizations
Shorouk O Badir1, Gary A Molander1
1Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Chem
|June 17, 2020
Summary
Nickel/photoredox dual catalysis enables mild C(sp3) center construction. Recent advances in photoinduced nickel-catalyzed difunctionalizations of alkenes/alkynes allow one-pot synthesis of two chemical bonds.
Area of Science:
- Organic Chemistry
- Catalysis
- Photochemistry
Background:
- Nickel/photoredox dual catalysis facilitates mild C(sp3) center construction.
- Existing methods are limited to single C-C or C-heteroatom bond formation.
- Challenges include competitive reactions and beta-hydride elimination.
Purpose of the Study:
- To review recent advances in photoinduced nickel-catalyzed 1,2-difunctionalization of alkenes and alkynes.
- To identify current challenges in this field.
- To discuss future perspectives for designing novel catalytic systems.
Main Methods:
- Exploration of recent literature on nickel/photoredox dual catalysis.
- Analysis of reaction mechanisms and limitations.
- Discussion of emerging catalytic system designs.
Main Results:
- Photoinduced nickel catalysis enables sequential construction of two chemical bonds in one pot.
- This approach offers mild reaction conditions and tolerance of diverse functional groups.
- Overcomes limitations of previous methods restricted to single bond formation.
Conclusions:
- Photoinduced nickel-catalyzed 1,2-difunctionalization represents a significant advancement in organic synthesis.
- Further research is needed to address challenges and develop new catalytic systems.
- This field holds great promise for efficient and versatile chemical bond construction.
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