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Updated: Dec 18, 2025

Longitudinal Measurement of Extracellular Matrix Rigidity in 3D Tumor Models Using Particle-tracking Microrheology
Published on: June 10, 2014
Hyperuniformity and density fluctuations at a rigidity transition in a model of biological tissues
Yuanjian Zheng1, Yan-Wei Li1, Massimo Pica Ciamarra2
1Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore. zhen0117@e.ntu.edu.sg massimo@ntu.edu.sg.
Abstract:
The suppression of density fluctuations at different length scales is the hallmark of hyperuniformity. Here, we explore the presence of this hidden order in a manybody interacting model of biological tissue, known to exhibit a transition, or sharp crossover, from a solid to a fluid like phase. We show that the density fluctuations in the rigid phase are only suppressed up to a finite lengthscale. This length scale monotonically increases and grows rapidly as we approach the fluid phase reminiscent to divergent behavior at a critical point, such that the system is effectively hyperuniform in the fluid phase. Furthermore, complementary behavior of the structure factor across the critical point also indicates that hyperuniformity found in the fluid phase is stealthy.
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