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Updated: Dec 18, 2025
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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
3.9K
GTDB: an integrated resource for glycosyltransferase sequences and annotations
Chenfen Zhou1, Qingwei Xu2, Sheng He1,3
1National Genomics Data Center, Bio-Med Big Data Center, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Xuhui, Shanghai 200031, China.
Summary
A new Glycosyltransferases Database (GTDB) catalogs over 520,000 enzymes, aiding research into bioactive compounds. This resource facilitates enzyme discovery and functional annotation for pharmaceutical and agrochemical applications.
Area of Science:
- Biochemistry
- Enzymology
- Bioinformatics
Background:
- Glycosyltransferases (GTs) are crucial enzymes synthesizing bioactive compounds with pharmaceutical and agrochemical potential.
- Comprehensive data on GTs, including sequences, structures, and functions, is essential for understanding their roles.
Purpose of the Study:
- To develop a centralized database (GTDB) for glycosyltransferases.
- To provide tools for searching, browsing, and analyzing GT data.
Main Methods:
- Collected extensive GT information: sequences, structures, reactions, and pathways.
- Developed sequence search algorithms and molecular docking processes.
- Integrated data into a searchable and browsable database with BLAST and docking simulation features.
Main Results:
- The GTDB contains 520,179 GTs from 21,647 species, involved in 394 reaction types.
- Features include text search, batch data download, BLAST for functional annotation, and GTdock for molecular simulations.
- The database facilitates efficient retrieval and analysis of GT information.
Conclusions:
- GTDB serves as a valuable resource for researchers studying glycosyltransferases.
- The integrated tools enhance the discovery and functional characterization of GTs.
- This database supports advancements in natural product discovery and enzyme engineering.
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