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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Frailty Assessment in an Aging Mouse Model
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Frailty, a multisystem ageing syndrome.

Janani Thillainadesan1, Ian A Scott2, David G Le Couteur1

  • 1Centre for Education and Research on Ageing (CERA) and Department of Geriatric Medicine, The University of Sydney and Concord Hospital, Sydney, Australia.

Age and Ageing
|June 17, 2020
PubMed
Summary

Frailty screening tools are entering clinical practice, but evidence for their widespread use is limited. A new framework focusing on aging biology biomarkers may improve frailty diagnosis and treatment.

Keywords:
ageingchronic diseasefrailtymultimorbidityolder people

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Area of Science:

  • Gerontology
  • Biomarkers of Aging
  • Clinical Geriatrics

Background:

  • Frailty management is crucial in aged care, with numerous screening tools developed.
  • Current frailty tools face challenges regarding evidence for widespread adoption, cost-effectiveness, and accuracy.
  • The term 'frailty' itself carries stigma among older adults, necessitating a re-evaluation of current approaches.

Purpose of the Study:

  • To propose a new framework for frailty management based on recent advances in aging biology.
  • To reconfigure the screening, diagnosis, treatment, and prevention of frailty.
  • To shift diagnostic criteria towards biomarkers of aging for improved interventions.

Main Methods:

  • Review of current frailty screening tools and their limitations.
  • Integration of recent scientific understanding of aging biology.
  • Development of a conceptual model linking aging biomarkers to frailty.

Main Results:

  • Limited evidence supports the widespread adoption of current frailty tools.
  • Foundational factors impact the accuracy and validity of existing frailty assessments.
  • A new model focusing on biomarkers of aging offers potential for improved frailty management.

Conclusions:

  • Current frailty management approaches require reconsideration due to limited evidence and stigma.
  • Advances in aging biology provide a novel framework for understanding and addressing frailty.
  • Focusing on biomarkers of aging can generate new targets for frailty prevention and treatment.