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Research Progress in Bioinspired Drug Delivery Systems
Qirong Tong1, Na Qiu1, Jianbo Ji1
1Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University , Jinan, PR China.
Expert Opinion on Drug Delivery
|June 17, 2020
Summary
Biomimetic drug delivery systems (BDDSs) utilize biological components like cells and exosomes for enhanced biocompatibility and targeting. These systems offer a promising alternative to traditional carriers for treating human diseases.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Traditional drug carriers face challenges including toxicity and immunogenicity.
- Biomacromolecules, cellular components, and exosomes are explored as biocompatible delivery vehicles.
- Biomimetic drug delivery systems (BDDSs) leverage these biological materials for advanced drug and gene delivery.
Purpose of the Study:
- To review BDDSs based on mammalian cells, proteins, pathogens, and extracellular vesicles (EVs).
- To highlight the advantages of BDDSs over traditional drug delivery systems (DDSs).
- To discuss the potential of BDDSs in overcoming limitations of natural carriers and treating diseases.
Main Methods:
- Focuses on a review of existing literature on BDDSs.
- Examines carriers derived from mammalian cells (blood, cancer, stem cells).
- Includes carriers based on endogenous proteins, pathogens, and extracellular vesicles (EVs).
Main Results:
- BDDSs exhibit superior biocompatibility, reduced side effects, and natural targeting capabilities compared to traditional DDSs.
- Bioengineering enables mimicking natural nanocarrier structures for diverse modifications.
- BDDSs can overcome limitations associated with natural materials and traditional carriers.
Conclusions:
- BDDSs represent a significant advancement in drug and gene delivery.
- They offer potential solutions to challenges posed by conventional drug carriers.
- BDDSs show a promising future for the treatment of various human diseases.
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