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Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies.

Maria Inês Teixeira1,2, Maria Helena Amaral1, Paulo C Costa1

  • 1UCIBIO-REQUIMTE, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

Pharmaceutics
|June 18, 2020
PubMed
Summary
This summary is machine-generated.

Microfluidic devices offer advanced models to study neurodegenerative diseases by simulating the blood-brain barrier. These systems also aid in developing novel nanocarrier drug delivery for the central nervous system.

Keywords:
Neurodegenerative diseases (NDs)blood-brain barrier (BBB)brain deliverybrain-on-a-chipcentral nervous system (CNS)drug deliverymicrofluidicsnanocarriersnanoparticles (NPs)organ-on-a-chip

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Area of Science:

  • Neuroscience
  • Biotechnology
  • Pharmacology

Background:

  • Neurodegenerative diseases (NDs) pose significant public health challenges.
  • Understanding the blood-brain barrier (BBB) and its central nervous system (CNS) interactions is crucial for developing effective therapies.
  • Current therapeutic strategies often face limitations in bioavailability and efficiency.

Purpose of the Study:

  • To review recent advances in microfluidic devices for CNS-targeted studies.
  • To highlight the application of microfluidics in simulating the BBB and studying NDs.
  • To cover microfluidic preparation of nanocarriers for CNS delivery.

Main Methods:

  • Review of existing literature on microfluidic devices and BBB models.
  • Discussion of microfluidic-integrated BBB models (BBB/brain-on-a-chip).
  • Analysis of microfluidic techniques for nanocarrier development and CNS drug delivery.

Main Results:

  • Microfluidic systems accurately simulate the BBB microenvironment.
  • BBB/brain-on-a-chip models show promise for studying NDs.
  • Microfluidics enables reproducible development of drug delivery systems with defined characteristics.

Conclusions:

  • Microfluidics is a powerful tool for advancing neurodegenerative disease research.
  • Microfluidic platforms enhance the study of BBB function and CNS drug delivery.
  • Future perspectives involve overcoming current challenges in microfluidic experimentation for CNS applications.