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Published on: February 18, 2022
Cold Plasma-Enabled Interface Engineering and In-Situ Functionalization of Printable Feedstocks in Additive
Xhoi Xibri1,2, Giuseppe F Racaniello2, Brendan Gilmore1
1School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.
Pharmaceutics
|July 28, 2026
Summary
Cold plasma (CP) offers precise, non-thermal surface modification for additive manufacturing (AM). CP enhances AM materials
Area of Science:
- Materials Science and Engineering
- Biomedical Engineering
- Surface Chemistry
Background:
- Additive Manufacturing (AM) enables personalized therapies and complex fabrication.
- Cold Plasma (CP) is a versatile surface engineering technology.
- Interactions between CP and AM for biomedical applications are underexplored.
Purpose of the Study:
- To review the potential interactions between cold plasma technologies and additive manufacturing processes.
- To explore applications in pharmaceutical and biomedical fields.
- To discuss challenges and future directions.
Main Methods:
- Literature review of CP applications in materials science.
- Analysis of CP's role in modifying AM surfaces.
- Discussion of engineering and regulatory considerations.
Main Results:
- CP can enhance interlayer adhesion, wettability, and bioactivity of AM materials.
- CP generates reactive species and functional groups on material surfaces.
- CP can impart antimicrobial properties to AM constructs.
Conclusions:
- CP is a promising technology for advanced surface modification in AM.
- Further investigation into CP-AM interactions is warranted for biomedical and pharmaceutical applications.
- Engineering and regulatory hurdles need to be addressed for clinical translation.

