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Gut Microbiome in Psoriasis: An Updated Review
Mariusz Sikora1, Albert Stec2, Magdalena Chrabaszcz1
1Department of Dermatology, Medical University of Warsaw, 02-091 Warsaw, Poland.
Pathogens (Basel, Switzerland)
|June 18, 2020
Summary
Psoriasis is linked to gut microbiome changes, specifically altered bacterial diversity and composition. Further research with standardized methods is needed to explore this gut-skin axis connection for potential therapies.
Area of Science:
- Microbiology
- Dermatology
- Gastroenterology
Background:
- Intestinal dysbiosis is increasingly recognized as a factor in psoriasis development.
- The gut-skin axis describes interactions between the gut microbiome and skin diseases via inflammation and metabolites.
- Understanding gut microbial composition in psoriasis is crucial.
Purpose of the Study:
- To systematically review and synthesize current data on gut microbial composition in psoriasis patients.
Main Methods:
- A systematic review adhering to PRISMA guidelines was performed.
- Searched MEDLINE, EMBASE, and Web of Science databases for studies published between 2000 and 2020.
- Included studies investigating intestinal microbiome in psoriasis.
Main Results:
- All 10 reviewed studies indicated alterations in gut microbiome in psoriasis patients.
- Significant changes in beta-diversity were consistently reported, while alpha-diversity showed mixed results.
- A lower abundance of Bacteroidetes and higher Firmicutes at the phylum level were noted in psoriasis patients.
Conclusions:
- A significant association exists between altered gut microbial composition and psoriasis.
- High heterogeneity among studies necessitates standardized methodologies for future research.
- Investigating the gut microbiome offers potential therapeutic strategies for psoriasis.
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