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Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive

Hirayuki Enomoto1, Hideji Nakamura2, Hiroki Nishikawa1

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine Nishinomiya, Hyogo 663-8501, Japan.

International Journal of Molecular Sciences
|June 18, 2020
PubMed

Insights

Hepatoma-derived growth factor (HDGF) promotes cell growth and survival. Its dysregulation is linked to cancer progression, suggesting HDGF as a potential therapeutic target for digestive malignancies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Hepatoma-derived growth factor (HDGF) was initially identified as a novel growth factor for hepatoma cells.
  • HDGF and four related proteins form a new gene family, implicated in cell growth, angiogenesis, and apoptosis.
  • While HDGF is vital for normal tissue development and repair, its overexpression correlates with poor prognosis in various cancers.

Purpose of the Study:

  • To provide an overview of HDGF's functions in both benign and malignant cells.
  • To explore the potential of HDGF as a therapeutic target for digestive malignancies.

Main Methods:

  • Literature review and synthesis of existing research on HDGF.
  • Analysis of HDGF's roles in cellular processes and disease states.

Main Results:

  • HDGF exhibits growth-stimulating, angiogenesis-inducing, and anti-apoptotic properties.
  • HDGF is widely expressed in normal tissues, aiding organ development and tissue repair.
  • Elevated HDGF expression is associated with aggressive clinical outcomes in several cancers.

Conclusions:

  • HDGF plays a dual role in normal tissue homeostasis and malignant progression.
  • HDGF represents a promising molecular target for the treatment of digestive malignancies.
Keywords:
HDGF-related proteinangiogenesisapoptosiscell growthdigestive malignancieshepatoma-derived growth factor (HDGF)nucleolin

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