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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Long Noncoding RNAs in Diffuse Large B-Cell Lymphoma: Current Advances and Perspectives.

Xianbo Huang1, Wenbin Qian2, Xiujin Ye1

  • 1Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People's Republic of China.

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Summary

Long noncoding RNAs (lncRNAs) show abnormal expression in Diffuse large B-cell lymphoma (DLBCL), a heterogeneous cancer. These lncRNAs are key to DLBCL development and may serve as diagnostic or therapeutic targets.

Keywords:
biomarkersdiffuse large B-cell lymphomalong noncoding RNA

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell malignancy with significant heterogeneity.
  • Despite advances, the precise pathogenesis of DLBCL remains incompletely understood.
  • Long noncoding RNAs (lncRNAs) have emerged as critical players in various cancers.

Purpose of the Study:

  • To review the role of lncRNAs in DLBCL.
  • To summarize the characteristics and functions of DLBCL-associated lncRNAs.
  • To discuss the clinical relevance of lncRNAs in DLBCL management.

Main Methods:

  • Literature review focusing on RNA sequencing studies.
  • Analysis of lncRNA expression patterns in DLBCL.
  • Examination of molecular mechanisms underlying lncRNA function in DLBCL.

Main Results:

  • Aberrant expression of numerous lncRNAs has been identified in DLBCL.
  • These lncRNAs are implicated in the development and progression of DLBCL.
  • Specific lncRNAs demonstrate potential as diagnostic biomarkers and therapeutic targets.

Conclusions:

  • lncRNAs are significantly involved in DLBCL pathogenesis.
  • Understanding lncRNA functions can enhance DLBCL diagnosis and treatment strategies.
  • Further research into lncRNAs holds promise for improving patient outcomes in DLBCL.