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Related Concept Videos

Brain Imaging01:14

Brain Imaging

568
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
568

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Related Experiment Video

Updated: Dec 18, 2025

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
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Understanding Cortical Dysfunction in Schizophrenia With TMS/EEG.

Aadith Vittala1, Nicholas Murphy2, Atul Maheshwari3,4

  • 1Department of Biosciences, Rice University, Houston, TX, United States.

Frontiers in Neuroscience
|June 18, 2020
PubMed
Summary
This summary is machine-generated.

Combined transcranial magnetic stimulation and electroencephalography (TMS/EEG) offers a non-invasive method to investigate neocortical dysfunction in schizophrenia. This review highlights TMS/EEG

Keywords:
TMS/EEGcortical correlatescortical inhibitiongamma oscillationsschizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurology

Background:

  • Schizophrenia involves neocortical dysfunction, necessitating advanced understanding for diagnostics and therapeutics.
  • Current understanding of schizophrenia's neurophysiological underpinnings requires further mechanistic exploration.

Purpose of the Study:

  • To review findings from studies utilizing combined transcranial magnetic stimulation and electroencephalography (TMS/EEG) in schizophrenia.
  • To elucidate the fundamental features of cortical dysfunction in schizophrenia using TMS/EEG.
  • To explore the potential of TMS/EEG in understanding schizophrenia's pathophysiological mechanisms.

Main Methods:

  • Utilizing combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) as a non-invasive neurophysiological assessment tool.
  • Simultaneously perturbing and measuring cortical activity, including oscillatory activity, cortical inhibition, connectivity, and synchronization.
  • Reviewing diverse studies that have applied TMS/EEG to investigate schizophrenia.

Main Results:

  • TMS/EEG has been applied across various studies to probe cortical function in schizophrenia.
  • The technique allows for the measurement of key neurophysiological markers relevant to schizophrenia.
  • Findings from TMS/EEG studies contribute to understanding cortical dysfunction in this disorder.

Conclusions:

  • Combined TMS/EEG is a valuable tool for investigating neocortical dysfunction in schizophrenia.
  • This methodology provides insights into the pathophysiological mechanisms underlying cognitive deficits in schizophrenia.
  • Future applications of TMS/EEG hold promise for advancing diagnostic and therapeutic strategies for schizophrenia.