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Published on: January 28, 2020
Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease
Nadia Bouzidi1, Mejdi Ben Messaoud2, Faouzi Maatouk3
1University of Monastir, Faculty of Pharmacy, Clinical and Molecular Biology Unit, Monastir, Tunisia.
Insights
High-sensitivity C-reactive protein (hsCRP) levels were not linked to coronary artery disease (CAD) severity. However, hsCRP shows potential for evaluating myocardial necrosis in ST-segment elevation myocardial infarction (STEMI) patients.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation
Background:
- Coronary artery disease (CAD) is a major cause of death and illness.
- Cytokines are implicated in atherosclerosis development and progression.
- This study examines the relationship between high-sensitivity C-reactive protein (hsCRP) and CAD severity.
Purpose of the Study:
- To investigate the association between hsCRP levels and the severity of coronary artery disease (CAD).
- To evaluate the predictive value of hsCRP in assessing myocardial necrosis in patients with ST-segment elevation myocardial infarction (STEMI).
Main Methods:
- Patients with CAD were divided into high (≥ 8.4 mg/L) and low (< 8.4 mg/L) hsCRP groups.
- CAD severity was determined by artery stenosis degree and the number of involved vessels.
- Statistical analysis was performed using SPSS version 23.0.
Main Results:
- No significant differences in biochemical risk factors or CAD severity were found between the hsCRP groups.
- Cardiac troponin I (cTnI) and serum amyloid A (SAA) were identified as predictors of hsCRP in multivariate analysis.
- Receiver operating characteristic (ROC) curve analysis indicated hsCRP (AUC: 0.905) is a powerful predictor of infarct size in STEMI patients, comparable to cTnI.
Conclusions:
- HsCRP levels are not associated with the severity of coronary artery disease (CAD).
- HsCRP can be a useful marker for evaluating myocardial necrosis in patients experiencing ST-segment elevation myocardial infarction (STEMI).
Background:
Coronary artery disease (CAD) remains a leading cause of morbidity and mortality. Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association between high sensitive C-reactive protein (hsCRP) and severity of CAD.
Methods:
CAD patients were stratified according to hsCRP cut-off value into high levels hsCRP group (≥ 8.4 mg/L) and low levels hsCRP group (< 8.4 mg/L). Severity of CAD was assessed according to artery stenosis degree and the number of vessel involved. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS, version 23.0).
Results:
The mean age was 60.3 ± 11.0 years. The level of hsCRP was increased and ranged from 0.2 to 1020.0 mg/L. Biochemical risk factors and severity of CAD didn't show significant differences between the two groups. In multivariate linear analysis, cardiac troponin I (cTnI) and serum amyloid A (SAA) were predictors of hsCRP. As shown in receiver operating characteristic (ROC) curve analysis performed in patients with ST-segment elevation myocardial infarction (STEMI) and compared to myonecrosis biomarkers, hsCRP (area under the curve (AUC): 0.905; 95%CI: 0.844-0.966; P < 0.001) could be a powerful predictor marker in evaluating the infarct size after myocardial infarction but not better than cTnI.
Conclusions:
HsCRP levels were not associated with the severity of CAD but could be useful in the evaluation of myocardial necrosis in patients with STEMI.
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