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Functional Landscape of Dysregulated MicroRNAs in Oral Squamous Cell Carcinoma: Clinical Implications

Ruma Dey Ghosh1, Arun Pattatheyil2, Susanta Roychoudhury3

  • 1Tata Translational Cancer Research Center, Tata Medical Center, Kolkata, India.

Frontiers in Oncology
|June 18, 2020
PubMed

Insights

MicroRNA (miRNA) alterations are key in oral squamous cell carcinoma (OSCC) development. Understanding these miRNA profiles offers potential for new diagnostic biomarkers and targeted therapies for personalized OSCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA (miRNA) dysregulation is implicated in the pathogenesis of oral squamous cell carcinoma (OSCC).
  • Translational research is exploring miRNA regulatory networks for precision oncology in cancer development.
  • Unique miRNA properties, including tissue-specific expression and presence in body fluids, suggest clinical utility.

Purpose of the Study:

  • To review recent research on miRNA alterations in OSCC.
  • To identify potential miRNA biomarkers for OSCC diagnosis and prognosis.
  • To discuss the scope of miRNA-based therapeutics for OSCC.

Main Methods:

  • Literature review of recent studies on miRNA profiles in OSCC.
  • Analysis of miRNA dysregulation in oral squamous cell carcinoma pathogenesis.
  • Evaluation of clinical significance and therapeutic potential of miRNAs in OSCC.

Main Results:

  • miRNA dysregulation is significantly associated with OSCC pathogenesis and patient outcomes.
  • Distinct miRNA expression signatures show promise as diagnostic and prognostic biomarkers.
  • miRNAs can serve as targets for novel therapeutic strategies in personalized OSCC treatment.

Conclusions:

  • Altered miRNA profiles are crucial in OSCC and hold potential for clinical applications.
  • miRNAs can be exploited as biomarkers for early diagnosis and prognosis of OSCC.
  • miRNA-based therapeutics represent a promising avenue for personalized treatment of OSCC.
Keywords:
dysregulated miRNAmiRNA biomarkermiRNA-based therapynon-invasive biomarkeroral squamous cell carcinoma

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