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Updated: Dec 18, 2025

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
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Published on: March 19, 2019

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Fungal infections in humans: the silent crisis

Katharina Kainz1, Maria A Bauer1, Frank Madeo1,2,3

  • 1Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.

Microbial Cell (Graz, Austria)
|June 18, 2020
PubMed

Insights

Fungal infections cause millions of severe cases and deaths annually, with rising numbers due to increased spread and drug resistance. More research is crucial to combat this growing global health threat.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Severe fungal infections affect over 150 million people globally each year, causing approximately 1.7 million deaths.
  • The incidence of fungal infections is increasing due to factors like global travel and immunocompromised populations.
  • Antifungal drug resistance is a significant concern, exacerbated by widespread therapeutic and prophylactic use.

Discussion:

  • Emergence of multidrug-resistant strains, such as Candida auris, poses a severe threat.
  • The rise in fungal infections is linked to societal and medical advancements.
  • Current antifungal treatments face challenges due to resistance development.

Key Insights:

  • Fungal infections represent a critical and escalating global health challenge.
  • Drug-resistant fungi are a major driver of increased mortality and morbidity.
  • Urgent need for enhanced research into novel antifungal strategies and diagnostics.

Outlook:

  • Future research must focus on developing effective treatments and preventative measures.
  • Continued surveillance and understanding of fungal pathogen dynamics are essential.
  • Interdisciplinary collaboration is vital to address the complex issue of fungal infections.
Keywords:
Candidaantifungalsantimycoticsazolesdrugresistanceyeast

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