Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions

Allergic Reactions

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Patch Clamp

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessment and Clinical Management of Patients With Atopic Dermatitis Undergoing Patch Testing: Recommendations From an International Electronic Delphi Consensus.

Dermatitis : contact, atopic, occupational, drug·2026

Same author

Minimal Systemic Exposure with Maximal Delgocitinib Cream Use in Patients with Severe Chronic Hand Eczema in the DELTA 2 Randomized, Vehicle-Controlled, Double-Blind, Phase 3 Trial.

Dermatology and therapy·2026

Same author

Comprehensive Patch Testing: An Essential Tool for Care of Allergic Contact Dermatitis.

Cutis·2026

Same author

Building consensus in pediatric dermatology research.

The Journal of investigative dermatology·2026

Same author

Beyond the Grid: A Case Series of Parent-Child Comprehension of Patch Testing Results.

Pediatric dermatology·2026

Same author

Occupational contact dermatitis in North American health care workers: Trends and triggers (2005-2022).

Journal of the American Academy of Dermatology·2026

Same journal

Harnessing Machine Learning and Electronic Health Record Data to Improve Asthma Management.

Current allergy and asthma reports·2026

Same journal

Incorporating New Guidelines into School-Based Asthma Management.

Current allergy and asthma reports·2026

Same journal

The Modern Environment and Childhood Asthma: The Role of Air Pollution and Heavy Metal Exposure.

Current allergy and asthma reports·2026

Same journal

Targeting Type 2 and Non-type 2 Asthma: Emerging Biologics and Personalized Strategies.

Current allergy and asthma reports·2026

Same journal

The Role of the Indoor Exposome in Food Allergy Development.

Current allergy and asthma reports·2026

Same journal

Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.

Current allergy and asthma reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 18, 2025

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Allergic Contact Dermatitis in Children: Recommendations for Patch Testing.

Idy Tam^1,2, JiaDe Yu^3,4

¹Tufts University School of Medicine, Boston, MA, USA.

Current Allergy and Asthma Reports

|June 18, 2020

Summary

This summary is machine-generated.

Allergic contact dermatitis (ACD) is common in children but often underdiagnosed. Patch testing, the gold standard, is now more standardized for pediatric patients, improving diagnosis and management.

Keywords:

Allergic contact dermatitis Children Patch testing Pediatric

More Related Videos

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Related Experiment Videos

Last Updated: Dec 18, 2025

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Area of Science:

Pediatric Dermatology
Allergology
Immunology

Background:

Allergic contact dermatitis (ACD) affects a significant portion of the pediatric population, yet diagnosis is frequently delayed or missed due to underrecognition.
Patch testing is the definitive diagnostic method for ACD in children, but its application presents specific challenges.
Limited standardized protocols historically hindered consistent ACD evaluation in pediatric cases.

Purpose of the Study:

To review the current literature on allergic contact dermatitis (ACD) in children.
To provide an update on the diagnosis and management of pediatric ACD.
To discuss the evolving methods and considerations for patch testing in pediatric populations.

Main Methods:

Literature review of recent studies on pediatric ACD and patch testing.
Analysis of challenges and specialized considerations for patch testing in children.
Highlighting the development and utility of a comprehensive pediatric baseline series for patch testing.

Main Results:

Recent research underscores the importance of ACD and the effectiveness of patch testing in children.
Effective ACD evaluation requires detailed exposure history, judicious allergen selection, and adapted testing techniques for pediatric cooperation.
The publication of a standardized pediatric baseline series in 2018 has facilitated more thorough ACD assessments.

Conclusions:

Improved diagnostic accuracy for pediatric ACD is achievable with current knowledge and tools.
Standardized patch testing protocols are crucial for the effective evaluation and management of ACD in children.
This review offers valuable insights for clinicians managing pediatric patients with suspected ACD.