SMARCA4-deficient uterine sarcoma: A case report and a concise review
Ali Kord1,2, Atul Eppurath2, Hamidou Drammeh2
1Division of Interventional Radiology, University of Illinois College of Medicine, Chicago, IL, USA.
Background:
SMARCA4-deficient uterine sarcoma (SDUS) is a newly discovered undifferentiated uterine mesenchymal malignancy which has loss of expression of SMARCA4.
Case:
A 46-year-old woman presented with heavy irregular vaginal bleeding over the previous 5 months. Computed tomography and magnetic resonance imaging showed a large pelvic mass centered within the uterus, suspicious of malignancy with regional metastatic lymphadenopathy. Biopsy confirmed SDUS and patient underwent chemotherapy. Her symptoms improved 3 months after treatment.
Conclusion:
An extremely rare case of this newly described entity is reported. Recognizing the characteristic imaging and pathology findings of SDUS is essential for an accurate diagnosis, which may affect patient survival.
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